EFFECTIVENESS OF A NEW ANTILEUKEMIC AGENT, THIOINOSINE (6-MERCAPTOPURINE RIBOSIDE)
نویسندگان
چکیده
منابع مشابه
Adsorption of 6-mercaptopurine and 6-mercaptopurine-ribosideon silver colloid: a pH-dependent surface-enhanced Raman spectroscopy and density functional theory study. II. 6-mercaptopurine-riboside.
Surface-enhanced Raman spectroscopy (SERS) has been applied to characterize the interaction of 6-mercaptopurine-ribose (6MPR), an active drug used in chemotherapy of acute lymphoblastic leukemia, with a model biological substrate at therapeutic concentrations and as function of the pH value. Therefore, a detailed vibrational analysis of crystalline and solvated (6MPR) based on Density Functiona...
متن کاملHost thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model.
BACKGROUND Thiopurines are used for many cancers, including acute lymphoblastic leukemia (ALL). Patients with an inherited host defect in thiopurine methyltransferase (TPMT) are at high risk for life-threatening toxicity if treated with conventional dosages, but the impact on antileukemic efficacy is less clear. MATERIALS AND METHODS We treated thiopurine-sensitive BCR-ABL+Arf-null Tpmt+/+ AL...
متن کاملEffects of Levamisole Administration on Treatment with 6-Mercaptopurine Riboside of Mice Bearing L1210 Leukemia Cells1
DBA/2 mice and BALB/c x DBA/2 F( mice were inoculated i.p. with 1 x 105 L1210 leukemia cells on Day 0. Beginning with Day 1 following inoculation, the animals were given injec tions of 6-mercaptopurine riboside (200 mg/kg i.p.) once daily for 5 consecutive days in combination with a single s.c. injec tion of levamisole (LMS) (10 mg/kg). In DBA/2 mice, a marked decrease in the total peritoneal c...
متن کاملEffects of levamisole administration on treatment with 6-mercaptopurine riboside of mice bearing L1210 leukemia cells.
DBA/3 mice and BALB/c X DBA/2 F1 mice were inoculated i.p. with 1 X 10(5) L1210 leukemia cells on Day 0. Beginning with Day 1 following inoculation, the animals were given injections of 6-mercaptopurine riboside (200 mg/kg i.p.) once daily for 5 consecutive days in combination with a single s.c. injection of levamisole (LMS) (10 mg/kg). In DBA/2 mice, a marked decrease in the total peritoneal c...
متن کامل6-Mercaptopurine, monocytes, and atherosclerosis.
Atherosclerosis, the underlying cause of heart attack and stroke, appears to be an inflammatory disease driven by retention of modified lipoproteins in the artery wall.1 Markers of inflammation, such as high sensitivity C-reactive protein, are independent predictors of cardiovascular (CV) events.2 If atherosclerosis truly is an inflammatory disease, then shouldn’t we be able to identify antiinf...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1971
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.20.177